Over-the-Counter Treatment for Vaginal Yeast Infections
For uncomplicated vaginal yeast infections, use topical azole antifungals available over-the-counter, such as clotrimazole 2% vaginal cream or miconazole 2% vaginal cream, applied intravaginally for 3-7 days. 1, 2
First-Line OTC Options
The following topical azole preparations are available without prescription and are highly effective for uncomplicated vulvovaginal candidiasis:
- Clotrimazole 2% vaginal cream: Apply intravaginally once daily for 3 days using the provided applicator 2
- Miconazole 2% vaginal cream: Apply intravaginally once daily for 3-7 days 3, 4
- Clotrimazole troches or other topical formulations: Various strengths and durations are available 1
These topical azole formulations achieve 84-90% success rates for acute vaginal yeast infections 3.
When OTC Treatment May Not Be Sufficient
You should seek prescription therapy rather than relying on OTC options if you have:
- Complicated vulvovaginal candidiasis (severe symptoms, recurrent infections, non-albicans Candida species, uncontrolled diabetes, immunosuppression, or pregnancy) 1
- Recurrent infections (4 or more episodes per year), which require longer treatment courses or chronic suppressive therapy 1, 3
- Symptoms that persist after completing a full OTC treatment course 3
Important Considerations
- Treatment duration matters: Complete the full course even if symptoms resolve earlier, as stopping treatment prematurely leads to higher recurrence rates 5
- Avoid if uncertain of diagnosis: If this is your first suspected yeast infection, consider seeing a healthcare provider for confirmation, as other vaginal infections can mimic yeast infection symptoms 3
- Prescription oral fluconazole (150 mg single dose) is more convenient but requires a prescription and is not available OTC in most jurisdictions 1, 3