What are the options to help manage an allergic reaction to Freestyle 2 (Flash glucose monitoring system) adhesive?

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Last updated: April 2, 2025 • View editorial policy

From the Guidelines

For individuals experiencing an allergic reaction to Freestyle Libre 2 adhesive, applying a barrier product between the skin and sensor adhesive, such as Skin-Prep, Cavilon barrier film, or Tegaderm, is a recommended first step to manage this issue. This approach creates a protective layer that can reduce direct contact with the allergens in the adhesive, as noted in the context of managing skin reactions with continuous glucose monitoring devices 1.

Some key options to consider for managing Freestyle Libre 2 adhesive allergy include:

  • Using over-the-counter antihistamines like cetirizine (10mg daily) or diphenhydramine (25-50mg as needed) to reduce allergic symptoms.
  • Applying topical hydrocortisone cream (1%) to the affected area after sensor removal to help reduce inflammation and itching.
  • Utilizing adhesive sensitivity reduction sprays specifically designed for medical devices.
  • Consulting with an allergist for prescription-strength topical steroids or patch testing to identify specific allergens, especially if symptoms persist or are severe.

It's also important to note that rotating sensor placement sites can give the skin time to heal between applications, which may help in managing the allergic reaction. The reactions are often due to compounds like acrylates or isobornyl acrylate in the adhesive, which can trigger contact dermatitis in sensitive individuals, as discussed in the context of diabetes technology standards of care 1.

From the FDA Drug Label

Directions for itching of skin irritation, inflammation, and rashes: adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily The answer to help with a freestyle 2 adhesive allergy is to apply hydrocortisone to the affected area not more than 3 to 4 times daily for adults and children 2 years of age and older, as it may help with skin irritation and inflammation. For children under 2 years of age, it is recommended to ask a doctor 2.

From the Research

Options to Help Freestyle 2 Adhesive Allergy

  • Using hydrocolloid-based plasters underneath the Freestyle 2 device has been shown to be effective in allowing patients with allergic contact dermatitis to continue using the device 3.
  • Identifying the specific allergen causing the reaction, such as isobornyl acrylate, can help in finding alternative devices or treatments 4, 5, 6, 7.
  • Collaboration between manufacturers, clinicians, and patient organizations is necessary to provide accurate information on the substances used in medical devices and to develop strategies for preventing and treating allergic contact dermatitis 5, 7.
  • Patch testing with the device's adhesive and potential allergens can help diagnose the specific cause of the allergic reaction 4, 5, 7.
  • Using alternative devices or systems that do not contain the identified allergen may be a viable option for patients with severe allergic contact dermatitis 7.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.