From the Research
There is no established contraindication between L-lysine supplements and Eliquis (apixaban), and patients can generally take L-lysine while on Eliquis, but it's always best to inform their healthcare provider about all supplements they're taking. While current evidence doesn't suggest a significant interaction between these substances, limited research exists specifically examining this combination. Eliquis is an anticoagulant that works by inhibiting Factor Xa in the blood clotting cascade, while L-lysine is an essential amino acid often taken as a supplement for various health purposes including cold sore prevention. Unlike some supplements that can affect blood clotting (such as high-dose vitamin E, ginger, or ginkgo biloba), L-lysine isn't known to significantly impact coagulation pathways or alter the effectiveness of Eliquis, as supported by studies on anticoagulant therapy and outcomes in patients with prior or acute heart failure and acute coronary syndromes 1. However, individual responses can vary, so it's essential to monitor for any unusual bleeding or bruising when combining these substances, and always disclose all supplements to the healthcare provider who manages the Eliquis therapy. The most recent and highest quality study on apixaban, which is the active ingredient in Eliquis, was published in 2025 and focused on extended reduced-dose apixaban for cancer-associated venous thromboembolism, but it does not provide specific information on interactions with L-lysine 2.
Some key points to consider when taking L-lysine with Eliquis include:
- Informing the healthcare provider about all supplements being taken
- Monitoring for unusual bleeding or bruising
- Understanding that individual responses to the combination of L-lysine and Eliquis can vary
- Recognizing that L-lysine is not known to significantly impact the effectiveness of Eliquis or increase the risk of bleeding, based on the available evidence 3, 4, 5.
It's crucial to prioritize the patient's safety and adjust the treatment plan accordingly, considering the potential risks and benefits of combining L-lysine with Eliquis, as discussed in the context of anticoagulant therapy and drug interactions 4.