What is the initial evaluation and management approach for a patient presenting with knee pain?

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Initial Evaluation and Management of Knee Pain

Begin with plain radiographs of the knee (minimum two views: anteroposterior and lateral) for all patients ≥5 years old presenting with knee pain, whether acute or chronic. 1, 2

History: Key Elements to Document

  • Age and onset pattern: Patients <40 years with anterior knee pain during squatting suggest patellofemoral pain (91% sensitive), while patients ≥45 years with activity-related pain and <30 minutes of morning stiffness suggest osteoarthritis (95% sensitive) 3

  • Mechanical symptoms: Document locking, catching, or giving way, which may indicate meniscal pathology (joint line tenderness 83% sensitive and specific; McMurray test 61% sensitive, 84% specific) 3

  • Red flags requiring urgent evaluation: Fever with joint swelling/erythema (septic arthritis), gross deformity, palpable mass, penetrating injury, inability to bear weight with severe pain/swelling after trauma 1, 2, 4

  • Weight-bearing ability and range of motion: Critical for applying Ottawa Knee Rules in acute trauma 1, 2

Physical Examination: Systematic Approach

  • Inspection: Assess for effusion, erythema, deformity, and muscle atrophy 4

  • Palpation: Check for focal tenderness over fibular head, isolated patellar tenderness, joint line tenderness, and warmth 1, 2

  • Range of motion testing: Document ability to flex knee to 90° (Ottawa criteria) and presence of crepitus 1, 4

  • Provocative maneuvers: Perform McMurray test for meniscal tears, patellar apprehension test for instability, and assess for ligamentous laxity 4, 3

  • Neurovascular examination: Essential to exclude referred pain from hip or spine pathology 4

Imaging Algorithm

For Acute Trauma (Use Ottawa Knee Rules)

Order radiographs if ANY of the following criteria are met: 1, 2

  • Age ≥55 years
  • Isolated patellar tenderness
  • Fibular head tenderness
  • Inability to flex knee to 90°
  • Inability to bear weight immediately after injury or take 4 steps in emergency department

Additional views beyond standard AP/lateral: Consider cross-table lateral, patellofemoral (sunrise), and oblique views for comprehensive evaluation 2

For Chronic Knee Pain (>6 weeks)

  • Initial radiographs should include: Frontal projection, tangential patellar view, and lateral view 1, 2

  • If radiographs are normal or show only effusion: MRI without contrast is usually appropriate as the next step to evaluate soft tissue structures, menisci, ligaments, and bone marrow lesions 1, 2

  • If radiographs show degenerative changes: MRI may be appropriate only when symptoms are not explained by radiographic findings or when stress fractures are suspected 1

  • Consider hip or lumbar spine radiographs: If knee radiographs are unremarkable and referred pain is suspected 2

Common Pitfalls to Avoid

  • Do not order MRI without recent radiographs first: This occurs inappropriately in ~20% of chronic knee pain cases 2

  • Recognize incidental findings: Meniscal tears are frequently present in asymptomatic older patients and may not be the pain source 2, 3

  • Avoid unnecessary imaging in acute trauma: Applying Ottawa rules can reduce radiographs by 23-35% while maintaining 100% sensitivity for fractures 1

When to Consider Advanced Imaging

  • CT without contrast: Appropriate when radiographically occult fractures are suspected (100% sensitive for tibial plateau fractures vs 83% for radiographs) or for detailed patellofemoral anatomy evaluation 1, 2

  • Ultrasound: Useful for confirming effusions, guiding aspiration, detecting Baker cysts, and evaluating superficial structures, but not as a comprehensive screening tool 1, 2

  • Joint aspiration: Indicated when infection or crystal disease is suspected, can be ultrasound or fluoroscopy-guided 1

Initial Management Based on Diagnosis

Osteoarthritis (Most Common in ≥45 Years)

  • First-line treatment: Exercise therapy, weight loss if overweight, education, and self-management programs 3
  • Avoid: Routine MRI in typical OA cases unless symptoms unexplained by radiographs 1

Patellofemoral Pain (Common in <40 Years, Active Patients)

  • First-line treatment: Hip and knee strengthening exercises combined with foot orthoses or patellar taping 3
  • No indication for surgery 3

Meniscal Tears

  • Conservative management first: Exercise therapy for 4-6 weeks, even with mechanical symptoms in degenerative tears 3
  • Surgery only for: Severe traumatic bucket-handle tears with displaced tissue 3

Urgent Referral Criteria

Immediate orthopedic consultation required for: 2, 4

  • Suspected septic arthritis (fever, severe swelling, erythema, limited ROM)
  • Severe pain with instability and inability to bear weight after acute trauma
  • Gross deformity or neurovascular compromise
  • Locked knee that cannot be extended

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Initial Workup for Knee Pain

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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