What is the appropriate diagnosis and treatment for a 23-year-old male with a one-week history of painless swelling of the left testicle?

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Painless Testicular Swelling in a Young Adult

This 23-year-old male with painless testicular swelling most likely has epididymitis or a hydrocele, but testicular torsion must be urgently excluded despite the atypical presentation, requiring immediate Doppler ultrasound evaluation. 1

Critical Initial Assessment

The absence of pain is atypical for testicular torsion but does not exclude it, particularly in cases of partial torsion or intermittent torsion. 1 The patient's description of the testicle feeling "up inside" his body raises concern for possible intermittent torsion with spontaneous detorsion, which can present with less severe or fluctuating symptoms. 1

Key clinical features to immediately evaluate:

  • Onset timing: Abrupt onset suggests torsion (even if painless), while gradual onset over days favors epididymitis 1
  • Cremasteric reflex: Though not perfectly reliable, its absence increases torsion suspicion 2
  • Testicular position and lie: High-riding or horizontal testis suggests torsion 1
  • Prehn sign: Pain relief with elevation suggests epididymitis, not torsion 1

Diagnostic Algorithm

Immediate Doppler ultrasound is mandatory to assess testicular perfusion, regardless of pain absence. 1, 3 The ultrasound should include:

  • Grayscale examination to assess testicular homogeneity and identify the "whirlpool sign" of twisted spermatic cord (96% sensitivity) 1
  • Color Doppler assessment of testicular perfusion comparing both testicles (96-100% sensitivity) 1
  • Power Doppler for enhanced detection of slow flow 1

Critical pitfall: False-negative Doppler evaluations can occur with partial torsion or spontaneous detorsion. 1 A normal ultrasound cannot definitively exclude torsion if clinical suspicion remains high. 2

Age-Specific Considerations

While testicular torsion is uncommon in adults over 25 years, it absolutely occurs in this age group and should not be dismissed. 1, 3 At 23 years old, this patient falls just outside the typical postpubertal peak but remains at risk. 1 Epididymitis is the most common cause of testicular symptoms in adults, representing approximately 600,000 cases annually in the United States. 1

Management Based on Ultrasound Findings

If decreased or absent testicular blood flow is detected:

  • Immediate urological consultation for surgical exploration without delay 1, 3
  • Testicular viability depends on intervention within 6-8 hours of true symptom onset 1
  • Even with one week of symptoms, if intermittent torsion is present, the testicle may still be salvageable 1

If normal blood flow with epididymal enlargement and hyperemia:

  • Diagnosis of epididymitis is confirmed 1
  • Obtain urinalysis (though normal urinalysis does not exclude epididymitis) 1
  • Treat with appropriate antibiotics based on age and risk factors
  • Supportive care with scrotal elevation, NSAIDs, and rest 1

If hydrocele or other benign findings:

  • Manage conservatively with observation
  • Urology referral for persistent or enlarging hydrocele

Additional Differential Considerations

  • Testicular tumor: Painless swelling in a young adult warrants consideration of malignancy, though typically presents as a firm mass rather than diffuse swelling
  • Varicocele: Usually described as "bag of worms" sensation, more common on left side
  • Inguinal hernia: The sensation of testicle being "up inside" could represent intermittent herniation of bowel into scrotum

Immediate Action Plan

Do not delay imaging with empiric antibiotic treatment in this patient. 3 The one-week duration and painless nature may falsely reassure, but partial or intermittent torsion can present exactly this way. 1 Order urgent Doppler ultrasound today, and if any concern for diminished flow exists, proceed directly to urological consultation for surgical exploration. 1, 3

References

Guideline

Testicular Torsion Diagnosis and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

High risk and low prevalence diseases: Testicular torsion.

The American journal of emergency medicine, 2023

Research

[Testicular torsion can also be present in adult men].

Nederlands tijdschrift voor geneeskunde, 2003

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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