Aklief (Trifarotene) Dosage for Acne Treatment
Apply a thin layer of Aklief Cream 0.005% once daily in the evening to clean, dry skin on affected areas. 1
Specific Application Instructions
Dosing by Body Area
- Face (forehead, cheeks, nose, chin): One pump actuation 1
- Upper trunk (reachable upper back, shoulders, chest): Two pump actuations 1
- Middle and lower back: One additional pump actuation if acne is present 1
Application Technique
- Apply to the entire affected area, not just individual lesions 1
- Use on clean and dry skin 1
- Apply in the evening only 1
- Avoid contact with eyes, lips, paranasal creases, and all mucous membranes 1
Essential Adjunctive Care
Moisturizer Use
- Use moisturizer as frequently as needed from treatment initiation 1
- This helps manage the expected dryness and irritation associated with retinoid therapy 1
Safety Considerations
Route of Administration
- Topical use only - not for oral, ophthalmic, or intravaginal use 1
Age Restrictions
- Approved for patients 9 years of age and older 2
Expected Adverse Effects
- Most common: pruritus, irritation, and sunburn 3
- These are typical retinoid-class effects and generally manageable with proper moisturization 3
Clinical Efficacy Data
Treatment Success Rates
- Facial acne: 65.1% achieved treatment success (no or almost no acne) at 52 weeks 3
- Truncal acne: 66.9% achieved treatment success at 52 weeks 3
- Overall success (both face and trunk): 57.9% 3
- Quality of life improvement: 52.8% of patients achieved minimal impact on quality of life compared to 22.6% at baseline 3
Key Clinical Advantages
Trifarotene is the first fourth-generation retinoid specifically approved for both facial and truncal acne, making it particularly valuable for patients with body acne 3, 2. Its selective RAR-γ agonist mechanism provides effective treatment with a manageable side effect profile when used as directed 2.