Where is Follicular lymphoma (a type of Non-Hodgkin Lymphoma) typically present?

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Last updated: April 2, 2025 • View editorial policy

From the Guidelines

Follicular lymphoma is primarily present in the lymph nodes throughout the body, most commonly in the neck, armpits, groin, and abdomen, as well as in the bone marrow, spleen, and other organs outside the lymphatic system. This type of non-Hodgkin lymphoma originates from B lymphocytes in the germinal centers of lymph node follicles, which explains its name 1. The disease typically presents as painless, enlarged lymph nodes that may wax and wane in size over time.

Key Characteristics of Follicular Lymphoma

  • It can also spread to involve other organs outside the lymphatic system
  • The disease is characterized by a slow growth pattern and is often widespread at diagnosis due to its indolent nature
  • Follicular lymphoma accounts for approximately 20-30% of all non-Hodgkin lymphomas and is more common in older adults, with the median age at diagnosis being around 60 years 1. In some cases, follicular lymphoma can be found in extranodal sites such as the gastrointestinal tract, skin, or central nervous system, though this is less common. The indolent nature of follicular lymphoma allows it to progress silently before causing noticeable symptoms, making early detection and treatment crucial for improving outcomes 1.

From the Research

Follicular Lymphoma Presence

  • Follicular lymphoma (FL) is a type of cancer that affects the immune system, specifically the lymphatic system 2, 3, 4, 5, 6.
  • The presence of follicular lymphoma can be identified in various parts of the body, including the lymph nodes, bone marrow, and spleen 2, 3, 4.
  • Advanced-stage follicular lymphoma can be present in multiple areas of the body, including the lymph nodes, liver, and bone marrow 2, 3.

Treatment and Prognosis

  • The treatment and prognosis of follicular lymphoma depend on various factors, including the stage and grade of the disease, as well as the patient's overall health 2, 3, 4, 5, 6.
  • Common treatment options for follicular lymphoma include rituximab-based regimens, such as R-CHOP and R-B, which have shown to be effective in improving outcomes and reducing toxicity 2, 3, 5, 6.
  • The prognosis for patients with follicular lymphoma varies depending on the stage and grade of the disease, as well as the response to treatment 4, 6.

Specific Locations

  • Follicular lymphoma can be present in the following specific locations: + Lymph nodes: Follicular lymphoma can affect the lymph nodes in the neck, armpits, and groin area 2, 3, 4. + Bone marrow: The disease can also affect the bone marrow, which can lead to anemia, fatigue, and other symptoms 2, 3, 4. + Spleen: In some cases, follicular lymphoma can affect the spleen, which can lead to enlargement of the spleen and other symptoms 2, 3, 4.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.