From the Guidelines
The outcomes in soft tissue trials using Negative Pressure Wound Therapy (NPWT) showed moderate desirable effects in reducing the time to healing in post-surgical wounds, but not in chronic wounds, with low certainty of evidence 1. The evidence from the studies analyzed showed that NPWT may reduce the time to healing in post-surgical wounds when provided in addition to standard of care, but the certainty of this evidence is low due to the moderate to high risk of bias in the studies 1. In terms of specific outcomes, the studies reported:
- Amputation was noted as an outcome in nine studies, with those at the lowest risk of bias showing no difference in amputation rates 1
- New infection was reported in five studies, with no difference between the groups, although all were at moderate or high risk of bias 1
- Resource utilization was documented in three studies, with reports of lower resource use or better cost-effectiveness than the comparator, although the certainty was thought to be low 1
- Quality of life was reported to be improved in one study at high risk of bias, but this should be treated with caution 1 Overall, the evidence behind the use of NPWT in soft tissue trials is of low certainty, and its effectiveness in reducing time to healing is still uncertain, particularly in chronic wounds 1.
From the Research
Outcomes in Soft and Text Trials
There are no research papers to assist in answering this question as the provided studies do not mention "soft and text trials". The studies focus on various topics such as:
- Interventions for enhancing medication adherence 2
- The necessity for clinical reasoning in the era of evidence-based medicine 3
- Strong recommendations from low certainty evidence in national guidelines 4
- Evidence-based clinical practice and threats to the validity of evidence 5
- Comparative efficacy and acceptability of antidepressant drugs for the acute treatment of adults with major depressive disorder 6
These studies do not provide information on "soft and text trials", therefore, it is not possible to determine the outcomes in such trials based on the provided evidence.