From the Research
Mean Platelet Volume (MPV) is a useful diagnostic marker for differentiating between underproduction and over-destruction of platelets as the causes of thrombocytopenia, with a cut-off value of 8.8 fL indicating over-destructive thrombocytopenia with acceptable sensitivity and specificity 1.
Key Points
- MPV is a measure of platelet size that can help distinguish between different causes of thrombocytopenia.
- A cut-off value of MPV ≥8.8 fL can indicate over-destructive thrombocytopenia with a sensitivity of 77% and specificity of 89% 1.
- The use of MPV as a diagnostic marker is supported by recent studies, including a systematic review and meta-analysis that found MPV to be a reliable and non-invasive tool for differentiating immune thrombocytopenic purpura (ITP) from hypo-productive thrombocytopenia 2.
- MPV has also been investigated as a potential biomarker for the risk and prognosis of heart disease, with some studies suggesting that it may be associated with an increased risk of ischemic stroke and cardiovascular events 3.
Clinical Implications
- MPV can be used as a diagnostic tool to help guide treatment decisions for patients with thrombocytopenia.
- A high MPV value may indicate over-destructive thrombocytopenia, such as ITP, and prompt further testing and treatment.
- MPV may also be useful in monitoring disease progression and response to treatment in patients with thrombocytopenia.
Limitations
- The use of MPV as a diagnostic marker is not without limitations, and further studies are needed to fully establish its clinical utility.
- MPV values can be influenced by various factors, including age, sex, and underlying medical conditions, and should be interpreted in the context of the individual patient's clinical presentation and laboratory results.