From the Research
Suitable Antidepressants for Individuals with Epilepsy
- The following antidepressants are considered suitable for individuals with epilepsy: + SSRIs (selective serotonin reuptake inhibitors) such as sertraline, citalopram, paroxetine, fluoxetine, escitalopram, and fluvoxamine 1, 2, 3 + SNRIs (serotonin and noradrenaline reuptake inhibitors) such as venlafaxine and duloxetine 1, 3 + Other antidepressants such as mirtazapine and reboxetine 1
- Anticonvulsive drugs that can be used in conjunction with antidepressants for individuals with epilepsy include valproate, carbamazepine, lamotrigine, gabapentin, and pregabalin 1
Antidepressants to Avoid in Individuals with Epilepsy
- The following antidepressants are not recommended for individuals with epilepsy due to their potential proconvulsant effects: + Amoxapine + Bupropion + Clomipramine + Maprotiline 1, 4
Considerations for Treatment
- The risk of antidepressant-associated seizures is generally considered low, and most antidepressants can be used safely in individuals with epilepsy 1, 4
- However, prescribers should be cautious when initiating treatment with antidepressants in individuals with epilepsy, and should consider the potential risks and benefits of treatment 2, 3, 5
- Good clinical management is essential to ensure safe and effective treatment of depression in individuals with epilepsy 5