What conditions can cause debilitating polyarticular pain due to ultraviolet (UV) radiation exposure?

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Differential Diagnosis for Crippling Multiple Joint Pain from Sun Exposure

  • Single most likely diagnosis
    • Lupus: This is a chronic autoimmune disease that can cause joint pain, skin rashes, and other symptoms. Sun exposure is a known trigger for lupus flares, which can lead to crippling joint pain.
  • Other Likely diagnoses
    • Psoriatic Arthritis: This condition is characterized by joint pain and skin psoriasis, which can be exacerbated by sun exposure. While not all cases are triggered by sun, it's a common enough association to consider.
    • Rheumatoid Arthritis: Although not typically triggered by sun exposure, some patients with rheumatoid arthritis may experience worsening symptoms due to increased inflammation caused by sun-induced heat.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Sickle Cell Crisis: Sickle cell disease can cause joint pain, and dehydration from sun exposure can trigger a sickle cell crisis, which is a medical emergency.
    • Porphyria: This group of rare genetic disorders can cause severe sun sensitivity, leading to blistering skin lesions and potentially crippling joint pain. Some forms of porphyria can be life-threatening if not promptly treated.
  • Rare diagnoses
    • Ehlers-Danlos Syndrome: This group of genetic disorders affects connective tissue and can cause joint hypermobility and pain. Some patients may experience worsening symptoms due to sun exposure, although this is not a primary characteristic of the condition.
    • Solar Urticaria: A rare condition characterized by hives and joint pain triggered by sun exposure. While not typically crippling, it can cause significant discomfort and should be considered in patients with unexplained sun-induced joint pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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