Can a long-standing umbilical (belly button) nevus (mole) present for over 13 years develop into melanoma?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 2, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

It is generally rare for a long-standing belly button mole that has been present for over 13 years without changes to suddenly develop into melanoma. Melanomas typically develop from new moles or from existing moles that begin to change in appearance. Moles that have remained stable in size, shape, color, and texture for many years are less likely to be malignant. However, any mole, regardless of its location or how long it has been present, should be monitored for changes using the ABCDE rule: Asymmetry, Border irregularity, Color variation, Diameter larger than 6mm, and Evolution or changes over time. The belly button area can make self-examination challenging, so having a healthcare provider examine any concerning moles is important.

Key Points to Consider

  • Risk factors that might increase concern include a family history of melanoma, previous sunburns, fair skin, or a large number of moles 1.
  • If you notice any changes in a long-standing mole, such as itching, bleeding, crusting, or any of the ABCDE characteristics, you should have it evaluated by a dermatologist promptly.
  • The USPSTF recommends that clinicians remain alert for skin lesions with malignant features noted in the context of physical examinations performed for other purposes, and that biopsy of suspicious lesions is warranted 1.
  • Individuals at higher risk of melanoma, such as those with a previous primary melanoma or large numbers of moles, should be counselled about this risk and taught how to self-examine for changing naevi 1.

From the Research

Melanoma Development from Belly Button Moles

  • There is limited research directly addressing the development of melanoma from belly button moles that have been present for over 13 years.
  • The provided studies focus on the treatment and management of melanoma, including surgical approaches, adjuvant therapies, and immunotherapies 2, 3, 4, 5, 6.
  • None of the studies specifically discuss the risk of melanoma development from long-standing belly button moles.
  • However, it is known that melanoma can arise from pre-existing moles, and factors such as the presence of ulceration, cytokine levels, and disease stage can influence the risk of melanoma development 2, 3.
  • The studies suggest that early detection and treatment of melanoma are crucial for improving outcomes, and that surgical management, adjuvant therapies, and immunotherapies can be effective in treating melanoma 3, 4, 6.
  • Further research is needed to determine the specific risk of melanoma development from belly button moles that have been present for over 13 years.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The use of interferon in melanoma patients: a systematic review.

Cytokine & growth factor reviews, 2015

Research

Surgical Management and Adjuvant Therapy for High-Risk and Metastatic Melanoma.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2016

Research

Surgical management of melanoma.

Seminars in cutaneous medicine and surgery, 2018

Research

Practice-Changing Developments in Stage III Melanoma: Surgery, Adjuvant Targeted Therapy, and Immunotherapy.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.