What is the recommended dose of Empagliflozin (Jardiance)?

From the Guidelines

The recommended dose of Empagliflozin (Jardiance) is 10 mg PO daily.

Empagliflozin Dosing

• The dose of Empagliflozin is recommended to be started at 10 mg PO daily for patients with type 2 diabetes and chronic kidney disease (CKD) with an eGFR ≥20 mL/min/1.73 m2 and urine albumin ranging from normal to 200 mg/g creatinine 1.
• According to the 2020 expert consensus decision pathway, Empagliflozin should be initiated at the lowest dose tested in CV and renal outcomes trials, which is 10 mg PO daily 1.
• No further dose titration is needed for CV or renal risk reduction, but dose increases may provide further glucose reduction benefits if indicated 1.
• It is essential to consider the patient's eGFR and adjust the dose accordingly, as Empagliflozin is not recommended for use in patients with eGFR <45 mL/min/1.73 m2 for glycemic control 1.

Important Considerations

• Empagliflozin can be started with eGFR >30 mL/min/1.73 m2, but it is crucial to monitor the patient's kidney function and adjust the dose as needed 1.
• The selection of specific agents, such as Empagliflozin, may depend on comorbidity and CKD stage, and it is recommended to use SGLT2 inhibitors in patients at high risk of CKD progression 1.
• Patients should be educated on the potential risks and benefits of Empagliflozin, including the risk of genital fungal infections, urinary tract infections, and euglycemic diabetic ketoacidosis 1.

From the FDA Drug Label

Table 1 presents the recommended dosage of JARDIANCE in adult and pediatric patients aged 10 years and older.

Population	Indication	Recommended Dosage
Adults	Reduce the risk of cardiovascular death and hospitalization in patients with heart failure	10 mg orally once daily in the morning, taken with or without food

                        | Reduce the risk of cardiovascular death in patients with type 2 diabetes mellitus with established cardiovascular disease | 10 mg orally once daily in the morning, taken with or without food
                        | Glycemic control in type 2 diabetes mellitus       | 10 mg orally once daily in the morning, taken with or without food. For additional glycemic control, may increase to 25 mg orally once daily in patients tolerating 10 mg once daily

Pediatric patients aged 10 years and older | Glycemic control in type 2 diabetes mellitus | 10 mg orally once daily in the morning, taken with or without food. For additional glycemic control, may increase to 25 mg orally once daily in patients tolerating 10 mg once daily

The recommended dose of Empagliflozin (Jardiance) is 10 mg orally once daily in the morning, taken with or without food, for most indications. For additional glycemic control in patients with type 2 diabetes mellitus, the dose may be increased to 25 mg orally once daily in patients tolerating 10 mg once daily 2.

From the Research

Recommended Dose of Empagliflozin (Jardiance)

The recommended dose of Empagliflozin (Jardiance) can be found in several studies, including:

• A 2015 study published in Revue medicale de Liege, which states that Empagliflozin is commercialized at doses of 10 mg and 25 mg once daily 3
• A 2017 meta-analysis published in Postgraduate medicine, which included double-blind, placebo-controlled trials of Empagliflozin at doses of 10 mg or 25 mg 4
• A 2019 systematic review and meta-analysis published in Journal of human hypertension, which included 12 randomized controlled trials of Empagliflozin at doses of 10 mg or 25 mg 5
• A 2021 study published in F1000Research, which investigated the pharmacokinetics and pharmacodynamics of Empagliflozin at a dose of 10 mg 6
• A 2024 meta-analysis published in Advances in therapy, which included data from four long-term trials of Empagliflozin at a dose of 10 mg 7

Key Findings

Key findings from these studies include:

• Empagliflozin is effective in reducing HbA1c, fasting plasma glucose, and body weight in patients with type 2 diabetes mellitus
• Empagliflozin is also effective in reducing blood pressure and uric acid in patients with type 2 diabetes mellitus
• The most common adverse events associated with Empagliflozin include hypoglycemia, genital and urinary tract infections
• Empagliflozin is considered safe and effective for the treatment of type 2 diabetes mellitus, with a recommended dose of 10 mg or 25 mg once daily

Dosing Information

Dosing information for Empagliflozin (Jardiance) includes:

• Recommended dose: 10 mg or 25 mg once daily
• Administration: taken orally, without regard to food
• Renal impairment: dose adjustment may be necessary in patients with severe renal impairment 3, 7, 4, 5