What are the high yield points from the Waterfall trial regarding antiretroviral therapy (ART) for Human Immunodeficiency Virus (HIV) infection?

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Last updated: November 28, 2025 • View editorial policy

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The WATERFALL Trial: High-Yield Points

I cannot provide high-yield points from the WATERFALL trial because this trial is not included in the evidence provided to me. None of the studies, guidelines, or drug labels reference a trial called "WATERFALL" related to antiretroviral therapy for HIV infection.

What the Evidence Does Include

The provided evidence contains information about several important HIV treatment trials, but not WATERFALL:

  • SPRING-2: Compared dolutegravir vs. raltegravir with 2 NRTIs in treatment-naïve patients 1, 2
  • SINGLE: Compared dolutegravir + EPZICOM vs. ATRIPLA in treatment-naïve patients 1, 2
  • FLAMINGO: Compared dolutegravir vs. darunavir/ritonavir with NRTIs 2
  • SAILING: Evaluated dolutegravir in treatment-experienced, INSTI-naïve patients 1, 2
  • VIKING-3: Studied dolutegravir in INSTI-experienced patients with resistance 1, 2
  • SWORD-1 and SWORD-2: Evaluated switching to dolutegravir + rilpivirine in virologically suppressed patients 1, 2
  • DISCOVER: Compared emtricitabine/tenofovir alafenamide vs. emtricitabine/tenofovir disoproxil fumarate for PrEP 3

Recommendation

If you are seeking information about a specific HIV treatment trial, please verify the trial name or provide additional context about what the WATERFALL trial investigated (e.g., specific drugs, patient population, or outcomes studied). I can then provide relevant information if it exists in available evidence sources.

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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