What is the total amount of Wegovy (semaglutide) needed for a 90-day supply at a dose of 2.4mg weekly?

Wegovy 90-Day Supply Calculation

For a patient on Wegovy 2.4 mg weekly maintenance dose, dispense 13 single-dose pens (2.4 mg/0.75 mL each) for a 90-day supply.

Dosing Calculation

• Wegovy is administered once weekly at the maintenance dose of 2.4 mg 1, 2
• For a 90-day supply: 90 days ÷ 7 days/week = approximately 12.86 weeks, which rounds to 13 doses 1
• Each pen contains a single dose of 2.4 mg/0.75 mL 1
• Total dispense: 13 pens of Wegovy 2.4 mg/0.75 mL 1

Important Clinical Context

Maintenance Dosing Considerations

• The 2.4 mg weekly dose is the maintenance dose reached after a 16-week titration schedule starting at 0.25 mg weekly 1, 2
• The titration schedule progresses: 0.25 mg (weeks 1-4) → 0.5 mg (weeks 5-8) → 1.0 mg (weeks 9-12) → 1.7 mg (weeks 13-16) → 2.4 mg (week 17 onwards) 1, 2
• Gradual titration is essential to minimize gastrointestinal adverse effects, which are the most common side effects 1, 2

Missed Dose Protocol

• If less than 5 days since missed dose: administer as soon as possible 1, 2
• If more than 5 days have passed: skip the missed dose and resume regular schedule 1, 2
• If 2 consecutive doses missed: consider resuming at same dose if previously well-tolerated, or lower the dose based on clinical judgment 1, 2
• If 3 or more consecutive doses missed: consider restarting the titration schedule 1

Storage and Administration

• Store in refrigerator (36°F to 46°F/2°C to 8°C); may be kept at room temperature for up to 28 days 1
• Can be administered at any time of day, with or without meals 1, 2

Clinical Efficacy Context

• At 68 weeks, semaglutide 2.4 mg achieved mean weight loss of 14.9% versus 2.4% with placebo 3, 4
• 86.4% of patients achieved ≥5% weight loss, and 50.5% achieved ≥15% weight loss 4
• Long-term use is necessary: after cessation, patients regained 11.6% of lost weight over 52 weeks 3