What is the diagnosis for Reflex Sympathetic Dystrophy (RSD)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 2, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for RSD (Reflex Sympathetic Dystrophy)

Single Most Likely Diagnosis

  • Complex Regional Pain Syndrome (CRPS): This is the most likely diagnosis as RSD is now more commonly referred to as CRPS Type I. It is characterized by chronic pain, inflammation, and hypersensitivity following an injury or trauma, which aligns closely with the symptoms of RSD.

Other Likely Diagnoses

  • Peripheral Neuropathy: Conditions affecting the peripheral nerves can mimic the pain and sensory changes seen in RSD/CRPS, making it a plausible differential diagnosis.
  • Fibromyalgia: Although it is a more generalized condition, fibromyalgia can present with widespread pain and tender points, which might be considered in the differential diagnosis for RSD.
  • Arthritis: Various forms of arthritis, especially those causing significant pain and inflammation in the affected limb, could be considered in the differential diagnosis.

Do Not Miss Diagnoses

  • Deep Vein Thrombosis (DVT): Although less likely, DVT can cause pain and swelling in a limb, similar to RSD/CRPS. Missing this diagnosis could lead to severe consequences, including pulmonary embolism.
  • Osteomyelitis: Bone infection can cause severe pain and might mimic some symptoms of RSD/CRPS. It requires prompt antibiotic treatment to prevent serious complications.
  • Compartment Syndrome: This is a medical emergency that can cause severe pain and limb swelling. It must be ruled out quickly to prevent permanent damage.

Rare Diagnoses

  • Erythromelalgia: A rare disorder characterized by burning pain, heat, and redness in the hands and feet. It could be considered in the differential diagnosis due to overlapping symptoms with RSD/CRPS.
  • Sjögren's Syndrome: An autoimmune disorder that can cause neuropathic pain among other symptoms, making it a rare but possible differential diagnosis.
  • Lyme Disease: In its later stages, Lyme disease can cause neurological symptoms and pain, which might be confused with RSD/CRPS in some cases.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.