Is there an interaction between Daflon (micronized purified flavonoid fraction) and paracetamol (acetaminophen)?

No Clinically Significant Interaction Between Daflon and Paracetamol

There is no documented drug interaction between Daflon (micronized purified flavonoid fraction) and paracetamol (acetaminophen), and these medications can be safely used together.

Evidence Base

Paracetamol Drug Interaction Profile

• Paracetamol has remarkably few clinically significant drug interactions documented in the medical literature 1
• No serious adverse drug interactions with therapeutic doses of paracetamol have been confirmed in humans, aside from potential warfarin potentiation and enzyme-inducing drugs in overdose scenarios 1
• The only documented interactions of clinical concern involve warfarin (controversial and dose-dependent) and enzyme-inducing medications that may potentiate hepatotoxicity in overdose situations 1

Daflon Safety Profile

• Daflon 500 mg demonstrates excellent safety with minimal side effects (10% of patients, primarily gastrointestinal or autonomic in nature) 2
• The medication has an LD50 exceeding 3 g/kg (180 times the therapeutic dose) with no toxic effects in animal studies at doses 35 times the daily therapeutic amount 2
• Clinical trials involving over 2,850 patients treated for 6 weeks to 1 year showed no significant hemodynamic or laboratory parameter alterations 2

Mechanism Considerations

Why No Interaction Is Expected

• Daflon's mechanism involves venous tone enhancement, lymphatic drainage improvement, and microcirculatory protection through anti-inflammatory and capillary permeability effects 3
• Paracetamol's metabolism occurs primarily through hepatic conjugation pathways (glucuronidation and sulfation), with only a small fraction metabolized by cytochrome P450 enzymes 1
• These distinct pharmacological pathways do not overlap or interfere with each other 1, 3

Safe Concurrent Use

Practical Application

• Both medications can be prescribed simultaneously without dose adjustment 1, 2
• Standard paracetamol dosing (maximum 1000 mg per dose, not exceeding 4000 mg daily) remains appropriate 4
• For chronic use, consider limiting paracetamol to ≤3000 mg daily to minimize hepatotoxicity risk 5
• Daflon's standard dosing of 2 tablets (1000 mg) daily remains unchanged when combined with paracetamol 2

Monitoring Requirements

• No additional monitoring beyond standard clinical practice is required for this combination 1, 2
• Routine liver function monitoring is not necessary unless other risk factors for hepatotoxicity exist 1