Closeril: Identification and Clinical Context
"Closeril" does not appear to be a recognized pharmaceutical agent in current medical literature or clinical guidelines. This term may represent a misspelling, regional trade name, or confusion with similarly-named medications.
Possible Intended Medications
Based on phonetic and spelling similarity, you may be referring to one of the following:
Closantel
- Closantel is a veterinary antiparasitic drug that is strictly contraindicated in humans 1
- Causes severe, irreversible visual loss even at low doses through destruction of neurosensory retina and visual pathways 1
- A case report documented complete bilateral blindness (no light perception) after ingestion of only three 500 mg tablets 1
- This drug should never be used in humans under any circumstances 1
Cilostazol (Pletal)
- A phosphodiesterase-III inhibitor indicated for intermittent claudication 2
- Dosing: 100 mg twice daily 2
- Significantly increases walking distances in patients with moderate to severe intermittent claudication compared to placebo and pentoxifylline 2
- Contraindicated in congestive heart failure, severe hepatic impairment, and severe renal impairment 2
- Requires dose reduction when coadministered with CYP3A4 or CYP2C19 inhibitors (erythromycin, diltiazem, omeprazole) 2
Clopidogrel (Plavix)
- An ADP receptor antagonist for prevention of atherothrombotic events 3, 4
- Standard dosing: 75 mg daily 5, 3
- Indicated for patients with recent MI, ischemic stroke, or established peripheral vascular disease 3
- In chronic coronary syndrome with prior MI or remote PCI, clopidogrel 75 mg daily is recommended as a safe and effective alternative to aspirin monotherapy 5
- Common adverse effects include increased bleeding risk, diarrhea, rash, and pruritus 3
- Has slow onset of action, irreversible platelet inhibition, and genetic variability in clinical potency 4
Clinical Action Required
Clarify the exact medication name immediately before proceeding with any clinical decision-making. If this involves a patient who has ingested an unknown substance, particularly if Closantel is suspected, urgent ophthalmologic evaluation and supportive care are indicated given the severe and irreversible visual toxicity 1.