What is the most likely diagnosis for a 6-month-old infant with a 7-day history of diarrhea, presenting with decreased skin turgor, sunken eyes, cold extremities, tachycardia, and hypotension?

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Hypovolemic Shock

This 6-month-old infant is in hypovolemic shock (≥10% fluid deficit) and requires immediate intravenous resuscitation. 1

Clinical Reasoning

The constellation of findings definitively indicates severe dehydration progressing to shock:

  • Cold extremities indicate poor peripheral perfusion and impending circulatory collapse 1
  • Tachycardia with hypotension (75/45 mmHg is low for a 6-month-old) represents hemodynamic instability 1, 2
  • Decreased skin turgor and sunken eyes are classic signs of moderate-to-severe dehydration 1, 3
  • 7-day duration of diarrhea has allowed progressive volume depletion 1

Dehydration Classification Framework

The CDC and AAP classify dehydration severity as follows 1, 2, 4:

  • Mild (3-5% deficit): Increased thirst, slightly dry mucous membranes
  • Moderate (6-9% deficit): Loss of skin turgor, dry mucous membranes, sunken eyes
  • Severe (≥10% deficit): Lethargy/altered consciousness, prolonged skin tenting, cool and poorly perfused extremities, decreased capillary refill, signs of shock

Why This is Hypovolemic Shock, Not Moderate Dehydration

Cool extremities are the critical distinguishing feature that elevates this from moderate to severe dehydration with shock 1. The CDC explicitly states that "cool and poorly perfused extremities" indicate severe dehydration (≥10% fluid deficit) requiring emergency intervention 1. The presence of hemodynamic compromise (tachycardia with hypotension) further confirms shock state 1.

While sunken eyes and decreased skin turgor alone might suggest moderate dehydration 1, 3, the addition of poor perfusion signs (cold extremities) and cardiovascular instability mandates classification as severe dehydration/hypovolemic shock 1, 5.

Immediate Management Required

Severe dehydration constitutes a medical emergency requiring immediate IV boluses of 20 mL/kg of Ringer's lactate or normal saline 1, 2. Treatment should continue until pulse, perfusion, and mental status normalize 1. This may require multiple IV lines or alternate access sites 1.

Once the patient stabilizes and consciousness returns to normal, transition to oral rehydration solution to replace remaining deficit 1.

Common Pitfall

The most dangerous error would be classifying this as moderate dehydration and attempting oral rehydration therapy alone. The presence of cold extremities and hemodynamic instability absolutely contraindicate oral rehydration as initial therapy 1, 2. Delayed recognition of shock significantly increases morbidity and mortality in infants 1.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Gastroenteritis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

How valid are clinical signs of dehydration in infants?

Journal of pediatric gastroenterology and nutrition, 1996

Guideline

Treatment of Gastroenteritis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

[Acute dehydration in infant].

Journal de pediatrie et de puericulture, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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