What is the typical dosing regimen for male to female hormone therapy, including estradiol (E2) and anti-androgens like spironolactone?

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Related Questions

In a 19‑year‑old transgender woman (assigned male at birth) with baseline male‑range total testosterone, thick facial hair, and normal erectile function, who is on estradiol and spironolactone and now has fluctuating testosterone levels with loss of nocturnal erections, how should anti‑androgen therapy be adjusted to achieve consistent testosterone suppression while preserving desired sexual function?

I'm a 19‑year‑old assigned male at birth with baseline testosterone ~654 ng/dL, thick facial hair and normal erectile function; after starting estradiol (up to 3 mg daily) and spironolactone (up to 100 mg daily) my testosterone dropped to ~180 ng/dL and I've lost spontaneous morning/nocturnal erections—should I adjust my hormone regimen to preserve spontaneous erections, and what target testosterone level is appropriate?

What are the functions and considerations of prescribing estradiol (an estrogen hormone) and spironolactone (an anti-androgen) for hormone therapy in a patient with a current medication regimen including Lamictal (lamotrigine)?

As a transgender woman taking oral estradiol 3 mg daily and spironolactone up to 200 mg daily, with serum testosterone between 180 and 437 ng/dL for several months and loss of nocturnal erections, why wouldn't this regimen and timeline cause permanent penile shrinkage?

In a 19‑year‑old transgender woman receiving estradiol up to 3 mg daily and spironolactone up to 50 mg twice daily, which has lowered serum testosterone to a low level, is this regimen likely to cause permanent penile atrophy (shrinkage)?

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