From the Research
Hyperthyroidism and Testosterone Levels in Women
- Hyperthyroidism has been found to be associated with decreased free testosterone (fT) levels in women, which may contribute to hypoactive sexual desire disorder (HSDD) or low libido 1.
- A study found that women with hyperthyroidism had lower mean total testosterone (tT) and free testosterone (fT) levels compared to healthy controls, and that the FSFI score showed a significant positive correlation with tT and fT levels 1.
- Another study found that genetic predisposition to hyperthyroidism was associated with increased sex hormone binding globulin (SHBG) and testosterone levels, but the relationship between thyroid function and sex hormones is complex and may vary between individuals 2.
Hyperthyroidism and Female Sexual Dysfunction
- Hyperthyroidism has been found to be a risk factor for female sexual dysfunction (FSD), with studies showing that women with hyperthyroidism have lower FSFI scores and higher rates of sexual dysfunction compared to healthy controls 1, 3.
- The prevalence of sexual dysfunction in women with hyperthyroidism has been estimated to be around 44-60%, with common symptoms including decreased libido, arousal, and orgasmic function 3, 4.
- Correction of hyperthyroidism to a euthyroid state has been associated with improvement in sexual function in women, suggesting that thyroid hormone derangements may play a causal role in FSD 3, 4.
Mechanisms Underlying Hyperthyroidism and Sexual Dysfunction
- The exact mechanisms underlying the relationship between hyperthyroidism and sexual dysfunction are not fully understood, but may involve changes in sex hormone levels, including decreased fT and increased SHBG 1, 2.
- Hyperthyroidism may also contribute to psychiatric and autonomic dysregulation, which can impair sexual function 3.
- Further research is needed to fully understand the relationship between hyperthyroidism and sexual dysfunction in women, and to develop effective treatments for FSD in this population 5, 4.