Differential Diagnosis for LOW MCHC, MCH, and 10.6 HGB related to Autoimmune Disease
- Single most likely diagnosis
- Autoimmune Hemolytic Anemia (AIHA): This condition is characterized by the immune system producing antibodies against the red blood cells, leading to their destruction. The low MCHC (mean corpuscular hemoglobin concentration), MCH (mean corpuscular hemoglobin), and hemoglobin (HGB) levels are consistent with anemia. AIHA is a common autoimmune cause of anemia and can present with these laboratory findings.
- Other Likely diagnoses
- Rheumatoid Arthritis (RA) with Anemia of Chronic Disease: RA is an autoimmune disease that can lead to anemia of chronic disease, characterized by low MCHC, MCH, and HGB due to chronic inflammation.
- Systemic Lupus Erythematosus (SLE) with Anemia: SLE is another autoimmune disease that can cause anemia, including AIHA, leading to similar laboratory abnormalities.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Paroxysmal Nocturnal Hemoglobinuria (PNH): A rare, acquired, life-threatening disease of the blood characterized by the destruction of red blood cells, bone marrow failure, and the potential for thrombosis. Although less common, it's critical to consider due to its severity and potential for fatal outcomes if not treated promptly.
- Cold Agglutinin Disease: A rare autoimmune disorder where the immune system produces antibodies that attack red blood cells at low temperatures, leading to their destruction. It can present with similar laboratory findings and requires specific treatment.
- Rare diagnoses
- Mixed Connective Tissue Disease with Anemia: A rare autoimmune disorder that combines features of lupus, scleroderma, and rheumatoid arthritis, which can lead to anemia.
- Sjögren's Syndrome with Anemia: An autoimmune disorder that primarily affects the glands that produce tears and saliva but can also lead to anemia in some cases.