From the FDA Drug Label
DESCRIPTION Triamcinolone Acetonide Injectable Suspension, USP is a synthetic glucocorticoid corticosteroid with anti-inflammatory action. ... Each mL of the sterile, off-white colored, aqueous suspension provides 40 mg triamcinolone acetonide USP, with 0. 66% sodium chloride for isotonicity, 0.99% (w/v) benzyl alcohol as a preservative, 0.63% carboxymethylcellulose sodium, and 0.04% polysorbate 80.
- The main ingredients in Kenalog are:
- Triamcinolone acetonide (40 mg/mL)
- Sodium chloride (0.66%)
- Benzyl alcohol (0.99% w/v)
- Carboxymethylcellulose sodium (0.63%)
- Polysorbate 80 (0.04%) 1
From the Research
Kenalog is a brand name for triamcinolone acetonide, a synthetic corticosteroid medication. The main active ingredient in Kenalog is triamcinolone acetonide, which works by reducing inflammation, suppressing immune responses, and decreasing allergic reactions in the body 2. Kenalog formulations typically contain this active ingredient along with various inactive ingredients that may include benzyl alcohol (as a preservative), carboxymethylcellulose sodium, polysorbate 80, and water for injection in injectable forms. For topical preparations, the vehicle may include petroleum jelly, mineral oil, or other emollients.
Key Points
- Kenalog is available in different forms including injections, topical creams, ointments, and aerosol sprays, with concentrations typically ranging from 0.025% to 0.5% for topical forms and 10 mg/mL to 40 mg/mL for injectable forms.
- The medication works by binding to glucocorticoid receptors in cells, which leads to decreased production of inflammatory substances like prostaglandins and leukotrienes, providing relief from inflammation, itching, and other symptoms.
- According to the most recent study, the unique nature of triamcinolone acetonide may be attributed to differing binding mechanisms, low solubility in blood, a low renal clearance rate, and various metabolites and other yet defined effects on skin 2. Some of the key benefits of Kenalog include:
- Reduced inflammation and immune responses
- Decreased allergic reactions
- Relief from itching and other symptoms
- Available in various forms and concentrations
- Generally well-tolerated with a tolerability profile similar to that of other corticosteroids 3.