Missing a Single Nighttime Dose of Progesterone in Early Pregnancy
Missing one 3 mg progesterone dose at night and taking the next scheduled dose the following morning will not cause problems in your early pregnancy. 1
Understanding the Timing and Risk
Your situation involves a dose that is less than 24 hours late, which is classified as a "late dose" rather than a truly missed dose, minimizing any potential risk 2, 1
Take your next scheduled 3 mg dose at 11 am as planned and continue with your regular dosing schedule 1
The gap between doses (approximately 24 hours from your morning dose to the next morning dose) maintains adequate progesterone levels to support early pregnancy 1
Why This Single Missed Dose Is Not Concerning
Progesterone supplementation in early pregnancy has a wide therapeutic window, and a single missed dose does not compromise pregnancy outcomes 2, 3
Studies examining progesterone for preterm birth prevention show that even with variations in dosing schedules, pregnancy outcomes remain favorable when overall compliance is maintained 2
The physiological changes of pregnancy create hormone reserves that buffer against brief interruptions in supplementation 3
What You Should Do Now
Continue taking your progesterone at 11 am daily without attempting to "make up" the missed nighttime dose 1
Do not take a double dose to compensate for the missed one 2, 1
Set daily reminders or alarms to help maintain consistent dosing going forward 1
Keep extra medication in multiple locations to ensure access 1
When to Contact Your Healthcare Provider
Contact your reproductive endocrinologist or obstetrician only if you experience unusual symptoms such as vaginal bleeding or cramping after missing the dose 1
If you miss multiple consecutive doses (≥48 hours without progesterone), contact your provider promptly 1
Document this missed dose to report at your next routine appointment 1
Important Context About Progesterone in Pregnancy
Progesterone plays a critical role in maintaining early pregnancy by supporting the endometrial lining and reducing uterine contractions 3
The route of administration (oral vs. vaginal) affects the drug's safety and efficacy profile, but both maintain adequate tissue levels even with minor dosing variations 3
Your early pregnancy is not at increased risk from this single missed dose, as the body maintains progesterone through multiple sources including the corpus luteum and developing placenta 3