From the Research
Interaction between Escitalopram and Metoclopramide
There are no research papers to assist in answering this question regarding the specific interaction between Escitalopram (Cipralex) and Metoclopramide.
General Information about Escitalopram
- Escitalopram is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of major depressive disorder (MDD) and anxiety disorder 1, 2, 3, 4.
- It has a highly selective, potent, and dose-dependent inhibitory effect on the human serotonin transport 2, 3.
- Escitalopram is effective and generally well tolerated in the treatment of moderate to severe generalised anxiety disorder (GAD) or social anxiety disorder (SAD), panic disorder (with or without agoraphobia) as well as obsessive-compulsive disorder (OCD) 4.
- It has a low propensity for drug interactions, which is a potential benefit in the management of patients with comorbidities 1, 5, 3.
Pharmacokinetics of Escitalopram
- Escitalopram is rapidly absorbed and reaches maximum plasma concentrations in approximately 3-4 hours after either single- or multiple-dose administration 5.
- The elimination half-life of escitalopram is about 27-33 hours and is consistent with once-daily administration 5.
- Escitalopram has low protein binding (56%) and is not likely to cause interactions with highly protein-bound drugs 5.
- It is metabolised by the cytochrome P450 (CYP) isoenzymes CYP2C19, CYP2D6 and CYP3A4, but in vitro studies have shown that escitalopram has negligible inhibitory effects on CYP isoenzymes and P-glycoprotein, suggesting that escitalopram is unlikely to cause clinically significant drug-drug interactions 5.