From the Guidelines
A platelet count of 519 is considered thrombocytosis.
Definition of Thrombocytosis
Thrombocytosis is generally defined as a platelet count above the normal range, which is typically considered to be above 450 x 10^9/L 1.
Diagnostic Criteria for Essential Thrombocythemia
According to the World Health Organization (WHO) criteria, a sustained platelet count of 450 x 10^9/L or higher is one of the diagnostic criteria for essential thrombocythemia (ET) 1.
Key Points
- A platelet count of 519 exceeds the threshold for thrombocytosis 1
- The WHO criteria for ET require a sustained platelet count of 450 x 10^9/L or higher, among other criteria 1
- The diagnosis of ET also requires the exclusion of other myeloid neoplasms and reactive thrombocytosis 1
From the Research
Definition of Thrombocytosis
Thrombocytosis is generally defined as a platelet count above 450×10^9/L 2.
Platelet Count of 519
A platelet count of 519 is considered above the normal range and meets the definition of thrombocytosis 2.
Classification of Thrombocytosis
Thrombocytosis can be classified as primary or secondary. Primary thrombocytosis is a clonal disease, while secondary thrombocytosis is a reactive process caused by various factors such as infection, chronic inflammation, iron deficiency, tissue damage, cancer, drugs, and surgical or functional splenectomy 3, 4.
Severity of Thrombocytosis
Thrombocytosis can be classified as mild, moderate, severe, or extreme based on the platelet count. A platelet count of 519 would be considered mild thrombocytosis 4.
Clinical Significance
The clinical significance of thrombocytosis depends on the underlying cause and the presence of symptoms. In some cases, thrombocytosis may be associated with an increased risk of thrombotic or hemorrhagic events 5, 3.