Nystatin Powder Dosing Interval
Nystatin topical powder should be applied 2 to 3 times daily to affected areas until healing is complete. 1
Standard Dosing Regimen
- Apply nystatin topical powder to candidal lesions 2 or 3 times daily until the infection has completely resolved 1
- This dosing interval applies to both adults and pediatric patients, including neonates 1
- Very moist lesions respond best to the topical dusting powder formulation rather than creams or ointments 1
Special Application Considerations
- For fungal infections of the feet caused by Candida species, dust the powder on the feet and inside all footwear to prevent reinfection 1
- Continue treatment until complete healing occurs, not just symptom resolution 1
- Store at controlled room temperature (15-30°C or 59-86°F) and avoid excessive heat above 40°C (104°F) 1
Important Clinical Context
This twice or three times daily interval differs significantly from oral nystatin suspension, which requires four times daily dosing for oral thrush 2, 3. The topical powder formulation allows for less frequent application because it maintains prolonged contact with the affected skin surface, whereas oral suspension must be repeatedly applied to maintain adequate mucosal contact.
The powder formulation is particularly useful for intertriginous areas, skin folds, and other moist environments where Candida thrives, as the powder helps reduce moisture while delivering antifungal activity 1.