Cost of Emicizumab 300mg Monthly Prophylaxis
I cannot provide specific pricing information for emicizumab 300mg monthly prophylaxis as the evidence does not contain location-specific cost data or actual drug pricing figures.
What the Evidence Shows About Costs
The cost of emicizumab varies substantially across different healthcare systems globally, and specific pricing information is not standardized in clinical guidelines. 1, 2
Key Cost Considerations from Guidelines
Global cost variability is significant: The International Society on Thrombosis and Haemostasis (ISTH) explicitly acknowledges that emicizumab costs differ substantially across healthcare systems and may not be affordable or available in all countries 2
Availability limitations: Emicizumab may not be registered or available in some countries, limiting its use regardless of cost-effectiveness 1, 2
Shared decision-making required: Treatment selection should consider availability of products, costs, and patient preference when choosing between emicizumab and alternative therapies 1, 2
Cost-Effectiveness Evidence (Not Actual Pricing)
While I cannot provide actual costs, the evidence demonstrates cost-effectiveness in several countries:
France: Emicizumab was dominant (less costly and more effective), saving €234,191 over 5 years compared to bypassing agents 3
Canada: Total lifetime cost estimated at $26.2 million CAD for emicizumab versus $27.2 million for standard half-life FVIII 4
Korea: Emicizumab prophylaxis reduced costs by $2.6 million USD over a lifetime compared to on-demand bypassing agents 5
Iran: Emicizumab was dominant in patients with annual bleeding rates ≥18 6
Important Caveats
Hemophilia care represents substantial costs: Factor replacement therapy accounts for approximately 80% of overall hemophilia care costs 1, 2
Implementation challenges exist: The large costs involved in prophylaxis for severe hemophilia A with inhibitors create substantial barriers, particularly in low- and middle-income countries 1, 2
How to Obtain Actual Pricing
To determine the specific cost for your location, you must:
- Contact the manufacturer (Genentech/Roche) directly for wholesale acquisition cost
- Consult your local pharmacy benefit manager or specialty pharmacy
- Review your specific insurance formulary and coverage policies
- Contact your hemophilia treatment center for local pricing information