What is the diagnosis and recommended treatment for a 6-year-old female patient with intermittent fever and excessive saliva production?

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Diagnosis and Management for 6-Year-Old Female with Intermittent Fever and Oral Lesions

This is most likely Herpangina or Hand-Foot-Mouth Disease (viral pharyngitis/stomatitis), and treatment should focus on supportive care with antipyretics and oral analgesics, not antibiotics. 1

Clinical Assessment

The presentation of intermittent fever (5 days, nocturnal pattern) with multiple oral ulcers ("singaw") extending to the tongue in a 6-year-old strongly suggests viral pharyngitis/stomatitis, most commonly caused by enteroviruses (Coxsackievirus A causing herpangina or hand-foot-mouth disease). 2

Key diagnostic considerations:

  • Viral etiology is most likely given the age (5-15 years peak for viral pharyngitis), fever pattern, and characteristic oral lesions 2
  • The absence of tonsillar exudates, anterior cervical lymphadenitis, or sudden-onset severe sore throat makes Group A Streptococcal (GAS) pharyngitis less likely 2
  • Viral causes include enteroviruses, herpesviruses, adenovirus, and other respiratory viruses 2, 3

Requested Laboratory Tests

CBC and Urinalysis are appropriate to:

  • Rule out bacterial infection (would show elevated WBC with neutrophil predominance) 2
  • Assess for lymphocytosis (typical in viral infections) 2
  • Exclude urinary tract infection as alternative fever source 1

Common pitfall: Ordering throat culture or rapid strep test without clinical features suggestive of GAS pharyngitis leads to overtreatment of viral carriers. 2

Medical Assessment/Diagnosis

Diagnosis: Acute Viral Pharyngitis/Stomatitis (likely Herpangina), rule out Hand-Foot-Mouth Disease

Clinical reasoning: 6-year-old female with 5-day history of intermittent nocturnal fever and multiple oral ulcerations consistent with viral etiology. No features suggesting bacterial pharyngitis (no tonsillar exudates, no anterior cervical lymphadenopathy, gradual onset). 2, 1

Treatment Plan and Recommendations

Medications (PhilHealth Konsulta Formulary-compliant, <300 pesos):

  1. Paracetamol 250mg/5mL syrup

    • Dose: 15mg/kg/dose every 4-6 hours as needed for fever >38.5°C
    • For 20kg child: 7.5mL (300mg) per dose
    • Dispense: 120mL bottle (sufficient for 5-7 days)
    • Duration: Until fever resolves 2, 1
  2. Oral rehydration solution (ORS) sachets

    • Dispense: 10 sachets
    • Instructions: Frequent small sips to maintain hydration 2, 1

No antibiotics indicated - this is a viral infection and antibiotics provide no benefit while increasing adverse effects and resistance. 2, 3, 4

Non-pharmacologic Management:

  • Soft, bland diet (avoid acidic, spicy, or hot foods) 1
  • Cold fluids and ice chips for oral pain relief 1
  • Rest until fever resolves 2, 1

Red Flags for Re-evaluation:

  • Fever persisting >7 days or worsening after initial improvement 2, 1
  • Development of respiratory distress, severe dehydration, or altered consciousness 2, 1
  • Inability to maintain oral intake 2, 1
  • Development of tonsillar exudates or severe throat pain (consider bacterial superinfection) 2

Medical Certificate

This certifies that patient has been seen and examined today with the diagnosis of: Acute Viral Pharyngitis/Stomatitis (Herpangina) and recommendation of: Home rest with supportive care, adequate hydration, and antipyretics as needed. May return to school once fever-free for 24 hours without antipyretics and able to eat/drink comfortably. This medical certificate is issued upon the request of the patient for school absence/return to school clearance.

Note: Patient is NOT fit to return to school until fever-free for 24 hours and able to maintain oral intake, to prevent transmission to other children. 1, 5

Patient/Parent Education

Explanation of condition: Your child has a viral infection affecting the mouth and throat, most likely caused by a common childhood virus called Coxsackievirus (herpangina). This causes painful sores in the mouth and fever that typically occurs at night. This is NOT a bacterial infection and does not require antibiotics. The illness is self-limiting and will resolve on its own within 5-7 days. The fever pattern (nocturnal) is typical for viral infections. Focus on keeping your child comfortable with fever control and maintaining hydration. The oral sores will heal without scarring. 2, 1, 5

References

Guideline

Acute Viral Syndrome Diagnosis and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Antibiotics for the common cold.

The Cochrane database of systematic reviews, 2002

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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