Can MenACWY (Meningococcal Conjugate Vaccine) and MenB (Meningococcal Serogroup B Vaccine) be administered in the same visit?

Yes, MenACWY and MenB Vaccines Can Be Administered During the Same Visit

MenACWY and MenB vaccines can and should be given at the same visit when both are indicated, using different anatomic sites for injection. 1

Clear Guideline Support

The Advisory Committee on Immunization Practices (ACIP) explicitly states there is no contraindication to giving meningococcal B and quadrivalent meningococcal conjugate vaccines on the same day as long as different administration sites are used. 1 This recommendation applies across age groups and risk categories. 1

Administration Requirements

When giving both vaccines simultaneously:

• Use different anatomic sites (e.g., left and right deltoid muscles) 1
• Administer both vaccines intramuscularly 1
• Do not mix vaccines in the same syringe 2
• Document each vaccine separately in the medical record 2

Clinical Context by Population

Routine Adolescent Vaccination

• MenACWY is routinely recommended at age 11-12 years with a booster at age 16 years 2
• MenB vaccination for ages 16-23 years is based on shared clinical decision-making 1, 2
• When both are indicated at the same visit (such as at age 16 for the MenACWY booster plus initial MenB series), they should be administered concomitantly 1

High-Risk Populations

For individuals with complement deficiencies, complement inhibitor use, or anatomic/functional asplenia:

• Both MenACWY and MenB are indicated 1, 2
• These vaccines should be administered at the same visit when possible to ensure timely protection 2
• MenACWY given as 2 doses ≥8 weeks apart; MenB given as either 2-dose or 3-dose series depending on product 2

Important Caveats

Product Interchangeability

• MenB vaccine products (MenB-FHbp/Trumenba and MenB-4C/Bexsero) are NOT interchangeable 1
• The same MenB product must be used for all doses in the series 1
• MenACWY products are also not interchangeable 1

Special Considerations for Young Children

• In children aged 2-6 years, MenACWY-D should ideally be given before, simultaneously with, or >6 months after DTaP due to potential immunologic blunting 1
• However, if travel to high-risk areas or outbreak situations exist, do not delay MenACWY-D administration 1
• MenACWY-CRM may be administered at any time relative to DTaP 1

Pentavalent Option

A newer pentavalent vaccine (MenACWY-TT/MenB-FHbp/Penbraya) is now available that combines both MenACWY and MenB components in a single injection for persons aged 10-25 years when both vaccines are indicated at the same visit. 3 This simplifies administration but is only compatible with the Pfizer MenB product for subsequent doses. 3

Rationale for Concomitant Administration

Simultaneous administration when both vaccines are indicated:

• Increases likelihood of complete vaccination 2
• Provides timely protection against all major meningococcal serogroups 2
• Does not compromise immune response to either vaccine 2, 4
• Improves compliance by reducing required visits 2