Robaxin (Methocarbamol) Dosing
For adults, initiate Robaxin at 1500 mg four times daily (6 grams/day) for the first 48-72 hours, then reduce to 1000 mg four times daily (4 grams/day) for maintenance. 1
Initial Dosing Phase (First 48-72 Hours)
- Standard initial dose: 6 grams per day divided into four doses 1
- For 500 mg tablets: 3 tablets four times daily 1
- For 750 mg tablets: 2 tablets four times daily 1
- Severe conditions: May increase to 8 grams per day during the initial treatment period 1
Maintenance Dosing (After 48-72 Hours)
- Target maintenance dose: Approximately 4 grams per day 1
- For 500 mg tablets: 2 tablets four times daily 1
- For 750 mg tablets: Either 1 tablet every 4 hours OR 2 tablets three times daily 1
Critical Safety Considerations
Avoid alcohol completely during methocarbamol therapy. The combination of methocarbamol and ethanol produces dangerous central nervous system depression due to their interactive sedative-hypnotic properties, which can be fatal even at therapeutic methocarbamol concentrations (24-41 mcg/mL) 2