Differential Diagnosis for Autoimmune Syndrome with Temporary Nodules Under the Skin
- Single Most Likely Diagnosis
- Rheumatoid Arthritis (RA): This condition is known for causing subcutaneous nodules, which are firm lumps under the skin, often found on the elbows, hands, or feet. These nodules can be temporary and are associated with the autoimmune nature of RA, making it a prime candidate for this presentation.
- Other Likely Diagnoses
- Lupus Erythematosus: Systemic lupus erythematosus (SLE) can cause a variety of skin manifestations, including nodules. While less common than other symptoms, lupus can lead to the formation of subcutaneous nodules as part of its autoimmune response.
- Sjögren's Syndrome: This autoimmune disorder primarily affects the glands that produce tears and saliva but can also cause skin manifestations, including nodules, due to its inflammatory nature.
- Dermatomyositis: An inflammatory disease characterized by skin rash and muscle weakness, dermatomyositis can sometimes present with subcutaneous nodules as part of its autoimmune pathology.
- Do Not Miss Diagnoses
- Granulomatosis with Polyangiitis (GPA): Formerly known as Wegener's granulomatosis, GPA is a rare autoimmune disorder that can cause nodules under the skin, particularly on the elbows and hands, but it can also affect internal organs, making early diagnosis critical to prevent serious complications.
- Eosinophilic Granulomatosis with Polyangiitis (EGPA): This condition, formerly known as Churg-Strauss syndrome, involves the blood vessels and is characterized by an excess of eosinophils, leading to various symptoms, including skin nodules. It's crucial to identify due to its potential for severe organ involvement.
- Rare Diagnoses
- Relapsing Polychondritis: A rare autoimmune disorder that affects cartilage, relapsing polychondritis can cause a variety of symptoms, including skin nodules, but it is much less common than other autoimmune conditions.
- Schnitzler Syndrome: Characterized by chronic urticaria, bone pain, and a monoclonal gammopathy, Schnitzler syndrome can also present with skin nodules. It's a rare condition that might be considered in the differential diagnosis due to its unique combination of symptoms.