From the Research
Over-the-counter progesterone supplements may not be the most effective treatment for perimenopausal brain fog symptoms, as the current evidence suggests that hormone therapy, including estrogen and progesterone, has a more favorable effect on menopausal symptoms, including cognitive function, when initiated close to menopause 1. The most recent and highest quality study on this topic, published in 2024, suggests that brain fog in menopause is a common complaint, and that clinicians can counsel women on how menopause symptoms, estrogen, hormone therapy, and modifiable risk factors can influence cognitive health 2. Some key points to consider when evaluating the effectiveness of over-the-counter progesterone supplements for brain fog include:
- The role of estrogen and menopause symptoms in cognitive changes during menopause 3
- The potential benefits and risks of hormone therapy on cognition and dementia risk in women 3
- The importance of modifiable risk factors for age-related cognitive decline and dementia, such as hypertension and sedentary lifestyle 2
- The need for individualized counseling and decision-making, taking into account a woman's medical history, symptoms, and preferences 3 It is essential to consult a healthcare provider before starting any hormone therapy, especially if you have a history of hormone-sensitive conditions, blood clots, or liver disease 1.