Storage Requirements for IV Co-Amoxiclav
IV co-amoxiclav must be stored at 2°C to 8°C (35°F-46°F) in a refrigerator and should never be frozen. [@2,3@]
Specific Storage Parameters
Temperature Requirements
- Maintain strict refrigeration at 2°C to 8°C (35°F-46°F) for unopened vials [@2,3@]
- Never freeze - freezing can irreversibly damage the medication's molecular structure and reduce efficacy 1
- Amoxicillin solutions are particularly unstable when stored between 0°C and -20°C, with rapid degradation occurring in partially frozen states 1
Storage Location Within Refrigerator
- Store centrally in the refrigerator, not in the door or on the bottom of the unit 2
- Keep sufficiently away from walls to allow air circulation 2
- Avoid placement near cold air outlets from freezer compartments in combination refrigerator/freezer units, as this can create temperature zones that may inadvertently freeze the medication 2
Temperature Monitoring Requirements
Active Monitoring Protocol
- Place calibrated thermometers in a central location adjacent to where medications are stored 2
- Document temperatures twice daily - once when opening and once at closing 2
- Maintain temperature logs for at least 3 years 2
- Assign primary and backup personnel responsible for monitoring 2
Immediate Action for Temperature Excursions
- Take immediate corrective action if temperatures fall outside the 2°C to 8°C range 2
- Do not use medication that has been exposed to freezing temperatures 1
- Recent evidence suggests some refrigerated medications may tolerate brief room temperature excursions, but specific data for IV co-amoxiclav stability at room temperature is limited 3
Critical Storage Pitfalls to Avoid
Common Errors
- Do not store food or beverages in the same refrigerator as medications - units should be dedicated to biologics only 2
- Avoid frost-free freezers for any storage, as temperature cycling can compromise stability 4
- Do not expose to direct heat, light, or excessive agitation 4
Visual Inspection Before Use
- Always check expiration date before administration 4
- Inspect for visible changes including clumping, precipitation, or changes in clarity or color - do not use if present 4