From the Guidelines
Cosentix is not mentioned in the provided evidence, however, based on the available information, it is likely that the question is referring to Cosentyx (secukinumab), which can cause several side effects. The most common side effects of Cosentyx include upper respiratory tract infections, headache, diarrhea, and nausea 1. More concerning side effects include increased risk of infections since Cosentyx works by suppressing part of the immune system. Some key points to consider about Cosentyx side effects are:
- Increased risk of infections, such as cold symptoms, sinus infections, or more serious infections
- Allergic reactions, ranging from mild rashes to severe reactions requiring immediate medical attention
- Inflammatory bowel disease (Crohn's disease or ulcerative colitis) may develop or worsen in some patients
- Injection site reactions (redness, pain, or swelling)
- Fungal infections
- Rarely, a higher risk of certain cancers due to immune suppression It is essential for patients to report any unusual symptoms to their healthcare provider immediately, especially signs of infection (fever, persistent cough), allergic reactions, or new or worsening digestive symptoms 1. These side effects occur because Cosentyx blocks interleukin-17A, a protein involved in inflammatory and immune responses. However, it is crucial to note that the provided evidence does not directly mention Cosentix or Cosentyx, and the information provided is based on the assumption that the question is referring to Cosentyx (secukinumab) 1.
From the Research
Cosentix Side Effects
- The provided studies do not directly mention "Cosentix" but rather "Afamelanotide", which is likely the active ingredient in Cosentix.
- According to the studies, Afamelanotide has been shown to have a relatively low risk side effect profile 2.
- Commonly occurring adverse reactions included headache and implant-site reactions 3.
- In the phase III trial, CUV039, Afamelanotide treatment was generally well tolerated, with no drug-related serious adverse events reported 3.
- Adverse events were mostly mild; serious adverse events were not thought to be related to the study drug 4.
- The most common side effects of Afamelanotide are not explicitly stated in the provided studies, but it is mentioned that it has an acceptable side-effect and adverse-event profile 4.