What is the diagnosis and treatment for an 18-year-old female with a 3-day history of worsening sore throat and odynophagia, presenting with symmetric erythematous tonsils, and possible differential diagnoses including viral pharyngitis, streptococcal (Group A beta-hemolytic streptococcal) pharyngitis, infectious mononucleosis, peritonsillar abscess, epiglottitis, and Lemierre's syndrome?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Article Review Status
Submitted
Under Review
Approved

Last updated: April 3, 2025 • View editorial policy

Differential Diagnosis for 18-year-old Female with Sore Throat and Odynophagia

  • Single most likely diagnosis + Viral pharyngitis: This is the most likely diagnosis due to the symmetric erythematous tonsils and the absence of specific symptoms pointing towards a bacterial infection. Viral pharyngitis is a common condition, especially in young adults, and often presents with sore throat, odynophagia, and erythematous tonsils.
  • Other Likely diagnoses + Streptococcal pharyngitis: Although less common than viral pharyngitis, streptococcal pharyngitis is a significant consideration due to its potential for complications if left untreated. The presence of symmetric erythematous tonsils does not rule out streptococcal pharyngitis, making rapid strep testing a crucial part of the diagnostic workup. + Infectious mononucleosis: This condition, caused by Epstein-Barr virus, can present with sore throat, fever, and lymphadenopathy. Although it's less common than viral pharyngitis, its symptoms can overlap, making monospot testing a useful diagnostic tool in certain cases.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed) + Peritonsillar abscess: Although less likely, a peritonsillar abscess is a serious condition that requires prompt diagnosis and treatment. It typically presents with severe odynophagia, fever, and a deviated uvula, but early stages might not show all these symptoms, making examination for asymmetry crucial. + Epiglottitis: This is a life-threatening condition that requires immediate recognition and treatment. Symptoms can include severe sore throat, difficulty swallowing, and shortness of breath. Although the patient's current symptoms do not strongly suggest epiglottitis, any signs of respiratory distress or severe odynophagia warrant immediate further evaluation. + Lemierre's syndrome: This rare but serious condition involves a bacterial infection of the jugular vein, often following a throat infection. It's characterized by fever, neck pain, and swelling, and can lead to sepsis if not treated promptly. The initial presentation might resemble a common throat infection, making it critical not to miss.
  • Rare diagnoses + Other rare bacterial or viral infections could potentially cause similar symptoms but are less likely and would be considered based on specific risk factors, exposure history, or failure to respond to initial treatment.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.