For epithelioid osteosarcoma, immunohistochemistry (IHC) is a critical diagnostic tool. The diagnosis typically involves a panel of markers to distinguish it from other bone and soft tissue tumors. Recommendations for IHC markers may include osteocalcin, osteonectin, and SATB2, among others, to confirm the osteoid production by the tumor cells, a hallmark of osteosarcoma. Given the rarity and aggressive nature of epithelioid osteosarcoma, a comprehensive diagnostic workup is essential. Treatment usually involves a combination of surgery, chemotherapy, and sometimes radiation therapy. Chemotherapy regimens may include doxorubicin, cisplatin, and ifosfamide, with the specific regimen tailored to the patient's overall health and the extent of the disease. In cases where the initial treatment is not effective, second-line interventions might include other chemotherapy agents or participation in clinical trials evaluating new therapies. It's essential to manage these patients in a multidisciplinary setting to optimize outcomes.
What is the role of immunohistochemistry (IHC) in diagnosing epithelioid osteosarcoma?
Last updated: December 3, 2025 • View editorial policy
Help us tailor your experience
Which best describes you? Your choice helps us use language that's most understandable for you.
Related Questions
Professional Medical Disclaimer
This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.
Have a follow-up question?
Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.