What causes redness of the inner eyelid (conjunctiva)?

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Last updated: April 3, 2025View editorial policy

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Differential Diagnosis for Inner Eyelid Redness

  • Single most likely diagnosis
    • Conjunctivitis: This is the most common cause of inner eyelid redness, often due to viral or bacterial infections, or allergic reactions. It presents with redness, discharge, and sometimes itching or burning sensation in the eyes.
  • Other Likely diagnoses
    • Blepharitis: Inflammation of the eyelids, which can cause redness, itching, and swelling of the eyelids, including the inner eyelid.
    • Dry eye syndrome: Insufficient tear production or poor tear quality can lead to redness, irritation, and discomfort in the eyes, including the inner eyelid.
    • Allergic rhinoconjunctivitis: Seasonal or perennial allergies can cause conjunctival redness, itching, and tearing, affecting the inner eyelid.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Acute angle-closure glaucoma: A medical emergency that can present with redness, severe eye pain, blurred vision, and headache. It requires immediate treatment to prevent vision loss.
    • Orbital cellulitis: A bacterial infection of the tissues surrounding the eye, which can cause redness, swelling, pain, and vision changes. It is a serious condition that requires prompt antibiotic treatment.
    • Sjögren's syndrome: An autoimmune disorder that can cause dry eyes, dry mouth, and other systemic symptoms. It may not be immediately life-threatening but can significantly impact quality of life if not managed properly.
  • Rare diagnoses
    • Sarcoidosis: A systemic inflammatory disease that can affect the eyes, causing uveitis, conjunctivitis, or other ocular symptoms, including inner eyelid redness.
    • Stevens-Johnson syndrome: A rare but serious disorder of the skin and mucous membranes, often triggered by medications or infections, which can cause eye symptoms including conjunctivitis and eyelid redness.
    • Granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis): A rare autoimmune disorder that can affect various parts of the body, including the eyes, and cause symptoms such as conjunctivitis and eyelid redness.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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