What is the next dose up from 0.75 mg of Truity (generic name unknown) for a patient?

Trulicity (Dulaglutide) Dose Escalation

The next dose up from Trulicity 0.75 mg is 1.5 mg once weekly, administered subcutaneously. 1

Standard Dosing Progression

Trulicity (dulaglutide) is a long-acting GLP-1 receptor agonist approved for type 2 diabetes mellitus with a specific dose escalation pathway. 1

Available doses in ascending order:

• 0.75 mg once weekly (starting dose)
• 1.5 mg once weekly (standard maintenance dose)
• 3.0 mg once weekly (higher maintenance dose)
• 4.5 mg once weekly (maximum dose)

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Clinical Decision-Making for Dose Escalation

When to escalate from 0.75 mg to 1.5 mg:

• If glycemic control remains inadequate after at least 4 weeks on the 0.75 mg dose
• If the patient tolerates the 0.75 mg dose without significant gastrointestinal side effects
• When HbA1c remains above individualized target despite adherence to current dose

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Administration Considerations

The 1.5 mg dose should be:

• Administered once weekly on the same day each week
• Given subcutaneously in the abdomen, thigh, or upper arm
• Continued for at least 4 weeks before considering further escalation to 3.0 mg if needed

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Common Pitfalls to Avoid

Do not escalate too rapidly - Allow at least 4 weeks at each dose level to assess glycemic response and tolerability, as GLP-1 receptor agonists require time to reach steady-state effects and for gastrointestinal adaptation. 1

Monitor for dose-dependent adverse effects - Nausea, vomiting, and diarrhea typically worsen with higher doses, so ensure the patient has tolerated the 0.75 mg dose before advancing. 1