From the Research
Effectiveness of Sildenafil for Treating a Thin Endometrium
- Sildenafil citrate has been shown to be effective in improving endometrial thickness in women with a thin endometrium, with some studies suggesting it can increase the clinical pregnancy rate and biochemical pregnancy rate 1, 2.
- A systematic review and meta-analysis found that sildenafil citrate significantly improved endometrial thickness, clinical pregnancy rate, and biochemical pregnancy rate in women with a thin endometrium 1.
- Another study found that sildenafil treatment resulted in a more noticeable reduction in the pulsatility index and a greater improvement in endometrial thickness compared to nifedipine 2.
- However, not all studies have found sildenafil to be effective in improving endometrial thickness, with one study finding that neither vaginal estradiol nor sildenafil significantly improved endometrial thickness or blood flow 3.
- A systematic review and meta-analysis of randomized controlled trials found that sildenafil supplementation improved endometrial thickness and clinical pregnancy rate in women undergoing ovulation induction, but not in women undergoing fresh or frozen embryo transfer 4.
Studies with Positive Findings
- A study published in 2006 found that vaginal sildenafil citrate improved endometrial thickness and achieved pregnancy in two women with Asherman's syndrome 5.
- A systematic review and meta-analysis published in 2020 found that sildenafil citrate improved endometrial thickness, clinical pregnancy rate, and biochemical pregnancy rate in women with a thin endometrium 1.
- A study published in 2023 found that sildenafil treatment resulted in a greater improvement in endometrial thickness compared to nifedipine in women with recurrent first-trimester miscarriages 2.
Studies with Negative Findings
- A study published in 2004 found that neither vaginal estradiol nor sildenafil significantly improved endometrial thickness or blood flow in women with a thin endometrium 3.
- A systematic review and meta-analysis published in 2021 found that sildenafil supplementation did not improve endometrial thickness or clinical pregnancy rate in women undergoing fresh or frozen embryo transfer 4.