What is the optimal timing for administering vaginal Sildenafil (sildenafil citrate) for a thin endometrium?

From the Research

Optimal Timing for Administering Vaginal Sildenafil

The optimal timing for administering vaginal Sildenafil for a thin endometrium is not clearly established in the provided studies. However, some studies suggest the following:

• Vaginal sildenafil citrate can be administered 3-10 days before embryo transfer to improve endometrial thickness 1
• Sildenafil citrate tablets (50 mg) can be given daily in addition to estradiol treatment from the first day of the cycle until the day progesterone is started, and discontinued 48-72 hours prior to embryo transfer 2
• The exact duration of treatment is not specified in other studies, but it is suggested that vaginal sildenafil can be used to improve endometrial thickness in women with a history of thin endometria 3

Factors Affecting Response to Sildenafil

Some studies suggest that the response to sildenafil may be affected by:

• History of endometritis, which may decrease the response to sildenafil 1
• Dosage and duration of treatment, which may vary depending on the individual patient's response 2, 1
• Method of administration, which can be either vaginal or oral 3, 2

Mechanism of Action

Sildenafil is thought to work by:

• Increasing intracellular nitric oxide (NO) production, which can improve uterine circulation and endometrial thickness 4
• Causing selective vasodilatation, resulting in improved endometrial development 3