From the Research
Estradiol Supplementation for Thin Endometrium with Femara (Letrozole)
- Estradiol supplementation has been shown to improve endometrial thickness and receptivity in women with thin endometrium, particularly when used in combination with Letrozole (Femara) 1.
- A study published in 2023 found that the addition of Letrozole to estrogen supplementation significantly increased endometrial thickness and improved clinical pregnancy rates in women with unresponsive thin endometrium 1.
- Another study from 2013 reported a successful pregnancy outcome in a woman with repeated implantation failure due to unresponsive thin endometrium after extended estrogen supplementation 2.
- The use of transdermal estrogens has been found to be effective in increasing endometrial thickness and improving pregnancy rates in women with thin endometrium, with significantly lower estrogen doses required compared to oral estrogens 3.
Factors Influencing Effectiveness of Estradiol Supplementation
- The effectiveness of estradiol supplementation in increasing endometrial thickness is influenced by factors such as maximal pretreatment endometrial thickness and treatment duration 4.
- A study from 2015 found that thinner endometrial thickness before estrogen treatment requires longer treatment duration and predicts poorer treatment outcomes 4.
- The quality of embryos transferred is an important predictor of assisted reproductive outcomes in patients treated successfully with exogenous estrogen 4.
Clinical Pregnancy Outcomes
- Clinical pregnancy rates have been found to be higher in women with thin endometrium who receive estradiol supplementation, particularly when used in combination with Letrozole (Femara) 1, 5.
- A case report from 2024 highlighted the possibility of successful live birth in a patient with extremely thin endometrium (3.8 mm) who received medications including Progynova, Aspirin, and Dydrogesterone, and underwent letrozole-induced ovulation 5.