From the Research
Effectiveness of Sildenafil for Treating Thin Endometrium
- The effectiveness of sildenafil in treating thin endometrium during the luteal phase is a topic of ongoing research, with studies yielding mixed results 1, 2, 3, 4, 5.
- A study from 2004 found that neither sildenafil nor vaginal estradiol improved endometrial thickness in women with thin endometria after taking oral estradiol in graduating dosages 1.
- In contrast, a 2021 systematic review and meta-analysis found that sildenafil supplementation improved endometrial thickness and pregnancy rate in women undergoing timed intercourses, but not in IUI and IVF treatments 2.
- Other studies have reported successful use of vaginal sildenafil citrate in increasing endometrial thickness and achieving pregnancy in women with varied uterine disorders, including Asherman's syndrome 3 and poor endometrial response in IVF patients 4.
- A randomized clinical trial from 2013 found that oral sildenafil citrate improved endometrial thickness and receptivity, and increased implantation and chemical pregnancy rates, although not significantly 5.
Key Findings
- Sildenafil may improve endometrial thickness and pregnancy rate in certain populations, such as women undergoing timed intercourses 2.
- The effectiveness of sildenafil in improving endometrial thickness and pregnancy outcomes may depend on the route of administration (vaginal vs. oral) and the specific patient population 2, 5.
- Further research is needed to fully understand the effects of sildenafil on endometrial thickness and pregnancy outcomes, particularly in the context of assisted reproduction techniques 2, 5.