From the Research
NAD+ injections should be administered at a dose of 250-500mg daily, with a recommended starting dose of 100-200mg for subcutaneous self-administration, as this range has been shown to be effective in boosting cellular NAD+ levels and improving energy production, DNA repair, and cellular resilience 1. When considering NAD+ daily injection dosing, it is essential to prioritize the most recent and highest quality study available. The study published in 2024 in the American Journal of Physiology, Endocrinology, and Metabolism 1 provides the most up-to-date and comprehensive evidence on the safety and effectiveness of NAD+ supplementation.
Key Considerations
- The injection should be given slowly over 5-10 minutes if subcutaneous, or 1-2 hours if intravenous, to minimize potential side effects like flushing or nausea.
- Treatment courses often run 5-10 days initially, followed by maintenance doses 1-3 times weekly.
- NAD+ should be stored refrigerated and reconstituted according to manufacturer instructions immediately before use.
- Individual responses vary, and this therapy remains investigational with limited long-term safety data.
Potential Benefits and Risks
- Boosting cellular NAD+ levels may improve energy production, DNA repair, and cellular resilience.
- Potential side effects include muscle pain, nervous disorders, fatigue, sleep disturbance, and headaches.
- Consulting with a healthcare provider experienced in NAD+ therapy is essential before beginning treatment to determine appropriate dosing for your specific health needs and to monitor for adverse effects.
Evidence Summary
- A systematic review of 10 studies with a total of 489 participants found that NAD+ supplementation was well-tolerated and associated with improved clinical outcomes, including decreased anxiety and maximum heart rate, increased muscle insulin sensitivity, and improved quality of life 1.
- Another study published in 2021 found that reduced nicotinamide mononucleotide (NMNH) was a potent NAD+ precursor that increased NAD+ levels to a higher extent and faster than other precursors 2.
- A review of the literature published in 2022 highlighted the potential benefits of NAD+ supplementation in preventing cognitive decline across disease contexts, including age-related cognitive decline, diabetes, stroke, and traumatic brain injury 3.