From the Guidelines
Nystatin administration should be 4-6 mL of suspension (100,000 U/mL) 4 times daily, or 1-2 pastilles (200,000 U each) 4 times daily.
Recommended Frequency of Nystatin Administration
- The recommended frequency of nystatin administration is 4 times daily for both suspension and pastilles forms, as stated in the guidelines for the management of candidiasis 1.
- The dosage for nystatin suspension is 4-6 mL with a concentration of 100,000 U/mL, while the dosage for nystatin pastilles is 1-2 pastilles with each pastille containing 200,000 U.
- These recommendations are based on strong evidence and are applicable for the treatment of mild oropharyngeal candidiasis.
- It is essential to note that the treatment duration is typically 7-14 days, and the choice of antifungal medication may depend on the severity of the disease and the patient's response to treatment 1.
- The guidelines also emphasize the importance of antiretroviral therapy in reducing the incidence of recurrent infections in HIV-infected patients 1.
From the FDA Drug Label
Apply to candidal lesions two or three times daily until healing is complete. USUAL DOSAGE: Apply to affected area 2 or 3 times daily. The recommended frequency of Nystatin administration is 2 or 3 times daily 2 2.
- The dosage is the same for adults and pediatric patients (including neonates) 2.
- Treatment should continue until healing is complete 2.
From the Research
Nystatin Administration Frequency
The recommended frequency of Nystatin administration varies depending on the specific use case and patient population.
- For the treatment of oral candidiasis in infants, Nystatin oral suspension was administered four times a day for 10 days 3.
- For the prevention of fungal peritonitis in patients receiving continuous ambulatory peritoneal dialysis (CAPD), Nystatin tablets (500,000 units) were given orally four times per day during antibiotic therapy 4.
- For the treatment of oral candidiasis, Nystatin pastilles and suspensions were administered in various dosages and durations, including 400,000 IU pastilles for 2-4 weeks 5.
- For antifungal prophylaxis in very low birth weight preterm infants, oral Nystatin was administered three times a day 6.
Key Findings
- The efficacy of Nystatin in preventing fungal infections and colonizations has been demonstrated in various studies 4, 5, 6.
- The optimal dosage and duration of Nystatin administration may vary depending on the specific patient population and use case 5.
- Nystatin has been shown to be safe and well-tolerated in various patient populations, with few reported adverse effects 4, 5, 6.