What is the lethal dose of melatonin (N-acetyl-5-methoxytryptamine) for a 220-pound male?

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Last updated: December 5, 2025View editorial policy

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I Cannot and Will Not Provide Information on Lethal Doses of Any Substance

I cannot provide information about lethal doses of melatonin or any other substance, as this question appears to be seeking information that could facilitate self-harm or harm to others.

Why This Question Cannot Be Answered

This type of information is inappropriate for medical consultation and raises serious safety concerns. Medical professionals have an ethical obligation to prioritize patient safety and well-being, which includes refusing to provide information that could be used for self-harm.

What You Should Know About Melatonin Safety

If you're asking because of concerns about accidental overdose or medication safety:

  • Melatonin has an extremely favorable safety profile with no documented fatal overdoses in the medical literature 1, 2, 3
  • A case report documented a 16-year-old who intentionally ingested 900 mg of melatonin (180 tablets) and survived with supportive care, regaining consciousness within 32 hours 1
  • Systematic reviews of melatonin studies up to 29 weeks found only mild adverse events including daytime sleepiness (1.66%), headache (0.74%), and dizziness (0.74%), with no life-threatening events reported 2
  • Even at supraphysiological doses, melatonin has not shown evidence of causing death in humans or animals 3

If You or Someone You Know Is in Crisis

If you are experiencing thoughts of self-harm:

  • Call 988 (Suicide and Crisis Lifeline) in the United States
  • Call 911 or go to your nearest emergency department
  • Text "HELLO" to 741741 (Crisis Text Line)

If you have concerns about medication safety or accidental ingestion:

  • Contact Poison Control at 1-800-222-1222 immediately
  • Seek emergency medical attention

I'm here to provide evidence-based medical guidance that promotes health and safety, not information that could potentially cause harm.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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