How do I apply adapalene (retinoid) gel?

How to Apply Adapalene Gel

Apply a thin film of adapalene gel once daily in the evening to the entire face and any other affected areas after washing gently with a non-medicated soap. 1, 2

Step-by-Step Application Instructions

Timing and Frequency

• Apply once daily in the evening only 1, 2
• Never apply more than once per day, as this will not provide faster results but will worsen skin irritation 2

Skin Preparation

• Wash the affected area gently with a non-medicated soap or gentle cleanser 1, 3
• Pat skin completely dry and wait 20-30 minutes before applying adapalene to reduce irritation potential 3
• Applying to completely dry skin is critical for minimizing adverse effects 3

Application Technique

• Use a pea-sized amount for each area of the face (forehead, chin, and each cheek) 1
• Apply a thin film to the entire face and any other affected areas, not just individual lesions 1, 2
• Cover the entire affected area with a thin layer—for example, if acne is on the face, apply to the entire face 2

Post-Application Care

• Wait 20-30 minutes after applying adapalene, then apply a non-comedogenic moisturizer to minimize dryness 3, 4
• This adjunctive moisturizer use significantly improves local tolerance and may contribute to better adherence 4

Critical Precautions and Common Pitfalls

Sun and Environmental Protection

• Minimize exposure to sunlight and sunlamps during treatment 1
• Weather extremes such as wind or cold may exacerbate irritation 1

Product Interactions to Avoid

• Avoid concomitant use of other potentially irritating topical products, especially those containing sulfur, resorcinol, or salicylic acid 1
• These combinations can significantly increase irritation beyond what adapalene alone causes 5

Managing Excessive Dryness or Irritation

• If excessive dryness develops, reduce application frequency to every other day or every third day until skin tolerance improves 3
• Consider using adapalene 0.1% instead of 0.3% if currently using the higher concentration 3
• The most common adverse effects include erythema, scaling, dry skin, burning/stinging, skin discomfort, pruritus, and desquamation 1

Age Restrictions and Contraindications

• Approved for patients ≥12 years of age 1
• Safety and effectiveness have not been established in pediatric patients <12 years of age 1
• Do not use if hypersensitive to adapalene or any components in the vehicle 1
• Pregnancy category C—use with appropriate counseling 1