Available Doses for Abilify Maintena
Abilify Maintena (aripiprazole long-acting injectable) is available in two doses: 300 mg and 400 mg, administered as a monthly intramuscular injection. 1, 2
Standard Dosing
- The recommended starting and maintenance dose is 400 mg administered once monthly as an intramuscular injection 2
- The 300 mg dose is available as an alternative maintenance dose for patients who may require dose adjustment 1
- Both doses are administered via intramuscular injection into the deltoid or gluteal muscle once every 4 weeks 2
Initiation Requirements
When starting Abilify Maintena 400 mg, patients must receive concomitant oral aripiprazole (10-30 mg daily) or continue their previous antipsychotic for 14 consecutive days to ensure therapeutic plasma concentrations are achieved 2
- Pharmacokinetic data demonstrate that median aripiprazole plasma concentrations reach therapeutic levels within 7 days of the first injection, but the 14-day overlap accounts for interpatient variability 2
- Mean aripiprazole plasma concentrations after 4 weeks (93-112 ng/mL) fall within the established therapeutic window (94.0-534.0 ng/mL) when this initiation protocol is followed 2
Alternative Initiation Method
A two-injection start regimen (AOM 400-TIS) is available as an alternative to the standard initiation, where patients receive two 400 mg injections on the same day without requiring oral supplementation 1
- This method eliminates the need for 14 days of oral aripiprazole supplementation 1
- European healthcare professionals report this approach is easy to administer and well tolerated, though some patients may be reluctant to receive two injections on the same day 1
Clinical Evidence for 400 mg Starting Dose
Across clinical studies, 90.1% (1296/1439) of patients initiated on the 400 mg dose required no dose adjustment, supporting 400 mg as the appropriate starting dose for most patients 2