How does uncoupling in HFpEF (Heart Failure with preserved Ejection Fraction) and altered HRV (Heart Rate Variability) impact hypertension?

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Last updated: December 6, 2025 • View editorial policy

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Related Questions

What is the biggest predictor for the development of Heart Failure with preserved Ejection Fraction (HFpEF)?

In a 68-year-old man with hypertension, dyspnea, orthopnea, paroxysmal nocturnal dyspnea, blood pressure 170/100, basal crackles, S4 gallop, systolic murmur, echocardiographic ejection fraction 55% with left‑ventricular hypertrophy and no wall‑motion or valvular abnormalities, which diagnosis is most likely: heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, ischemic cardiomyopathy, or cor pulmonale with right‑ventricular failure?

In a 68-year-old man with hypertension presenting with dyspnea, orthopnea, paroxysmal nocturnal dyspnea, basal lung crackles, an S4 gallop, an ejection murmur, and echocardiography showing a normal ejection fraction of 55% with left ventricular hypertrophy and no regional wall‑motion or valvular abnormalities, what is the most likely diagnosis?

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