Amoxicillin Dosing for a 175-pound Male Adult
For a 175-pound (79 kg) male adult, the standard amoxicillin dose is 500 mg three times daily (every 8 hours) for mild-to-moderate infections, or 875 mg twice daily (every 12 hours) for more severe infections. 1
Standard Dosing Regimens
Mild-to-Moderate Infections
- 500 mg every 8 hours (three times daily) is the standard dose for most mild-to-moderate ear/nose/throat, skin/skin structure, and genitourinary tract infections 1
- Alternatively, 500 mg every 12 hours (twice daily) can be used for mild infections 1
Severe Infections
- 875 mg every 12 hours (twice daily) is recommended for severe infections of the ear/nose/throat, skin/skin structure, and genitourinary tract 1
- 500 mg every 8 hours (three times daily) is an alternative for severe infections 1
Lower Respiratory Tract Infections
- 875 mg every 12 hours or 500 mg every 8 hours for both mild-to-moderate and severe lower respiratory tract infections 1
Specific Clinical Scenarios
Erysipeloid (Skin Infection)
- 500 mg three times daily for 7-10 days 2
H. pylori Infection
- 1 gram (1000 mg) twice daily when used in triple therapy with clarithromycin and lansoprazole for 14 days 1
- 1 gram three times daily when used in dual therapy with lansoprazole for 14 days 1
Streptococcal Infections
- 1000 mg once daily for 10 days is an acceptable alternative regimen for acute Group A streptococcal pharyngitis 3
- Treatment must continue for at least 10 days to prevent acute rheumatic fever 1
Important Administration Guidelines
Timing and Food
- Take amoxicillin at the start of a meal to minimize gastrointestinal intolerance 1
Duration of Therapy
- Continue treatment for a minimum of 48-72 hours beyond when symptoms resolve or bacterial eradication is documented 1
- For any Streptococcus pyogenes infection, at least 10 days of treatment is mandatory to prevent acute rheumatic fever 1
Common Pitfalls to Avoid
- Do not use 875 mg dose in patients with severe renal impairment (GFR <30 mL/min); use 500 mg or 250 mg every 12-24 hours depending on severity 1
- Do not substitute two 250 mg tablets for one 500 mg tablet when using amoxicillin-clavulanate formulations, as this results in excessive clavulanate dosing 3
- Ensure adequate hydration and monitor for allergic reactions, particularly in patients with penicillin allergy history 1